Leydig cell function in mice lacking connexin43

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Leydig cell function in mice lacking connexin43.

Connexin43 (Cx43) is the most abundantly expressed member of the connexin (gap junction protein) family and the only one so far identified in mouse Leydig cell gap junctions. Mice lacking Cx43 were used to investigate its role in testicular androgen production and regulation. Testes from term fetuses were grafted under the kidney capsules of castrated adult males. After 3 weeks, serum from host...

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Leydig Cell Function in Man

In humans, as in all mammalian males, Leydig cells are the main source of the androgenic hormone, testosterone, which is essential for male sexual differentiation, gamete production and maturation, and development of secondary sexual characteristics. In this chapter, the development, steroidogenic function, and regulation of human Leydig cells are summarized. Clinical aspects of androgen secret...

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ژورنال

عنوان ژورنال: Reproduction

سال: 2006

ISSN: 1470-1626,1741-7899

DOI: 10.1530/rep.1.01234